Effects of cholera toxin on adenylate cyclase. Studies with guanylylimidodiphosphate.
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منابع مشابه
Effects of cholera toxin on adenylate cyclase. Studies with guanylylimidodiphosphate.
Similarities exist between the properties of adenylate cyclase after stimulation by cholera toxin and after stimulation by guanylylimidodiphosphate (Gpp-(NH)p). Thus a strong stimulation is achieved by both agents, the stimulation is essentially irreversible, the action of certain hormones is enhanced and the enzyme can be solublized with Lubrol PX in the activated state. Because of these simil...
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Preincubating turkey erythrocytes with cholera toxin alters their adenylate cyclase (EC 4.6.1.1) system: basal activity, maximal epinephrine-stimulatable activity, and affinity of the enzyme reaction for epinephrine are all increased. Pretreatment of erythrocytes with choleragenoid prevents these changes. Cholera toxin does not alter [(3)H]epinephrine uptake by intact erythrocytes. The increase...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1975
ISSN: 0021-9738
DOI: 10.1172/jci108213